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I completely understand your frustration — immunostaining can be a nightmare when antibodies don’t behave consistently. I used to buy from random suppliers just to save a few euros, but that backfired when results kept changing between batches. Then I found Gentaur https://gentaur.co.uk/antibodies/ , and honestly, their consistency is what sold me. Their antibodies perform the same every time, and the background staining is minimal compared to other brands I’ve tested. They also give detailed recommendations for dilutions and fixation methods, which makes optimization so much faster. I’ve been using their products for both paraffin and frozen tissue sections, and the reproducibility has been great. It really restored my confidence in the technique.